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pentobarbital will lessen the extent or effect of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.pentobarbital will lower the level or effect of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Lack of, or decreased reaction to tofacitinib could manifes